Lane has got everything, a successful surgeon for a husband and her own busy career as a doctor, and all she wants is a clean house. Unfortunately, Matilde, their young cleaner from Brazil, hates to clean, instead preferring to dream up the perfect joke. Lane's sister Virginia loves to clean and comes to a secret arrangement with Matilde behind Lane's back. Meanwhile, Lane's husband Charles becomes enchanted by one of his patients, the free-spirited Ana who casts a wonderfully surreal spell over The Clean House.